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The commenter indicated that this conclusion was based on the limited weight gain or lack of weight gain found in animals given these steroids compared to control animals not exposed to the steroids. A large series of reviews of studies have noted that the relationship between growth hormone levels and muscle growth appears to be similar in rats and humans.25,26 Although these studies typically focused on animals fed diets that were similar in terms of animal feed source (for example, animal byproducts), there is also sufficient evidence to suggest that steroid-induced muscle growth may occur in nonhuman primates.17–19,28–32 These studies have demonstrated that the growth hormone in the animals fed dietary supplements and supplemented human subjects was of unknown origin, and the growth effect may have evolved as a consequence of their lack of growth hormone.17,17,30 The evidence for steroid-induced growth in humans is also relatively equivocal. In a review of the literature, the authors point out that there is not sufficient evidence to establish an effect size of the size of the relationship between growth hormone level and muscle size on human adults and children, but they do note that the evidence is sufficient for the suggestion that growth hormone treatment may be an effective means by which to reverse muscle wasting. The lack of an impact on the body weight of the nonhuman primate is concerning. It may be that the observed results cannot fully explain the apparent weight loss, and hence that the effect size was only modest in nature. Indeed, it is possible that the effect size of the study may have only been modest, when considering only the effect on the average weight and body circumference of the treated animals. Alternatively, it may be that the effect size could have been small, relative to total measured body weight but not in comparison to absolute body weight. However, even if the result are weak and unlikely to account for any of the reported weight loss over time, the results are still compelling in their relationship between growth hormone level and body weight. It remains a matter of dispute if the effect of growth hormone treatment on body weight of nonhuman primates is a cause, an effect or an independent variable in a body-wide, population-based study. However, the large, uncontrolled cohort studies have identified a positive relation between plasma growth hormone level and body weight.17–19 In addition, in humans, the data suggest that the effect of growth hormone treatment on body weight can be reversed by restricting intake of high-protein supplements. In primates, no such effect is found, and body-weight regain and total body weight gain may be greater.17,17,32,34 Although the lack of a positive relation between the increase in body-weight and growth hormone Similar articles: